Patents

Title WO number Status
Procedure for producing uronic acid block from alginate WO1998/51710 Granted, various territories
Use of G-block polysaccharides WO1998/02488 Granted, various territories
Use of oligouronates for treating mucus hyperviscosity WO2007/039754 Granted, various territories
Oligo-guluronate and galacturonate compositions WO2008/125828 Granted, various territories
Use of alginate oligomers in combating biofilms WO2009/068841 Granted, various territories
Parenteral pharmaceutical composition for use in gene therapy WO2010/109176 Granted, various territories
Composition for the administration of polymeric drugs WO2010/109180 Granted, various territories
Treatment of Acinetobacter with alginate oligomers and antibiotics WO2010/139956 Granted, various territories
Alginate oligomers for overcoming multidrug resistance in bacteria WO2010/139957 Granted, various territories
Use of alginate oligomers to enhance the effects of antifungal agents WO2013/038197 Granted, various territories
New mutant strains of Pseudomonas fluorescens and variants thereof, methods for their production, and uses thereof in alginate production WO2004/011628 Granted, various territories
Mucosal treatment WO2007/039760 Granted, various territories

Peer Reviewed Publications

Jack AA, et al. Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum-Sensing Systems in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 2018 Apr 26; 62(5). doi: 10.1128/AAC.02318-17.

 

Rye PD, et al. Alginate oligomers and their use as active pharmaceutical drugs. In “Alginates and their Biomedical Applications” Springer Series in Biomaterials Science and Engineering (Vol. eds. Rehm H.A. and Moradali F.), 2018, Vol 11. Published Springer Singapore.

 

Pritchard MF, et al. Alginate Oligosaccharides modify hyphal infiltration of Candida albicans in an In Vitro Model of Invasive Human Candidosis. J. Appl Micro. 2017, Sep;123(3):625-636.

 

Tøndervik A, et al. Alginate oligomers inhibit growth of bacteria causing bovine mastitis and potentiate the activity of antibiotics commonly used for treatment of the disease. J. Adv. Dairy Res. 2017 5:186. doi: 10.4172/2329-888X.1000186

 

Pritchard MF, et al. A low molecular weight alginate oligosaccharide disrupts pseudomonal microcolony formation and enhances antibiotic effectiveness. Antimicrobial Agents and Chemotherapy 2017 Aug 24;61(9).

 

Pritchard MF, et al. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports. 2017, Mar 31;7:44731. doi: 10.1038/srep44731.

 

Ermund A, et al. OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin Exp Pharmacol Physiol. 2017 44, 639-647.

 

Vitko M, et al. A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice. J Cyst Fibros. 2016 Nov 15(6):745-751.

 

Pritchard MF, et al. A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease. Mol Pharm. 2016 Mar 7;13(3):863-72. doi: 10.1021/acs.molpharmaceut.5b00794. Epub 2016 Feb 16.

 

Hengzhuang W, et al. OligoG CF-5/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model. Antimicrob Agents Chemother. 2016 60, 2620-2626.

 

Nordgård CT, et al. Alterations in mucus barrier function and matrix structure induced by guluronate oligomers. Biomacromolecules. 2014 Jun 9;15(6):2294-300.

 

Tøndervik A, et al. Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of antifungals against Candida and Aspergillus spp. PLoS One. 2014 Nov 19;9(11):e112518.

 

Powell LC, et al. A nanoscale characterization of the interaction of a novel alginate oligomer with the cell surface and motility of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol. 2014 Mar;50(3):483-92.

 

Roberts JL, et al. An in vitro study of alginate oligomer therapies on oral biofilms. J Dent. 2013 Oct;41(10):892-9.

 

Powell LC, et al. The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling. 2013;29(4):413-21.

 

Sletmoen M, et al. Oligoguluronate induced competitive displacement of mucin–alginate interactions: relevance for mucolytic function. Soft Matter, 2012, 8, 8413.

 

Khan S, et al. Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics. Antimicrob Agents Chemother. 2012 Oct;56(10):5134-41.

 

Nordgård CT, Draget KI. Oligosaccharides as modulators of rheology in complex mucus systems. Biomacromolecules. 2011 Aug 8;12(8):3084-90.